• Shop For Gift Certificates
  • Book Now
  • Call Us: 123-123-1234
Call Us1300 THYROID (1300 849 764)
HealthHub Login
Free Consult
Call Us1300 THYROID (1300 849 764)
The Lucy Rose Clinic The Lucy Rose Clinic
  • Home
  • Our Approach
    • FAQ
    • Thyroid Practitioners
    • Discover the Thyroid Gland
    • Testing
    • Locations
  • Reviews
  • Conditions
    • Thyroid Nodules
    • Graves’ Disease
    • Hashimoto’s Disease
    • Thyroid and Fertility
    • Thyroid Cancer
    • Thyroid Testing
  • Podcast
  • Articles
  • Contact Us

Thyroid Test List And Deiodinases

You are here: Home / Conditions / Autoimmune / Thyroid Test List And Deiodinases

Thyroid Test List And Deiodinases

May 24, 2021March 30, 2022by Lucy Rose Clinicin Autoimmune, Complementary Practices, Diagnosis & Testing, Thyroid, Thyroid ConditionsTags thyroid, thyroid testing education

Thyroid Testing and Examination

Here is the list of thyroid specific testing:

  • Thyroid stimulating hormone (TSH): This test is the initial indicator or thyroid disorders. TSH is produced by the anterior pituitary gland after stimulation from thyrotropin releasing hormone (TRH) secreted by the hypothalamus. TRH then triggers the pituitary gland to release TSH. The level of TSH rises when thyroid hormone levels (T4) in the blood decline. Conversely, the level of TSH declines as the thyroid hormone (T4) level in the blood rises.
  • Free T4 – Measures thyroxine that is not attached to proteins. This level of free hormone is what exerts the biological effect. This test shows how the hormone affects the functioning of many types of body cells.
  • Triiodothyronine (Free T3): Measures the level of T3 in the blood. This is the active form of thyroid hormone and exerts direct influence to the cells. If your Free T3 levels are low or high you will have symptoms.
  • Antithyroglobulin (anti-Tg) antibodies: This test is used to diagnose autoimmune thyroid disease. (Graves’/Hashimoto’s Diseases). 
  • Antithyroid peroxidise (anti-TPO) antibodies: This test is used to diagnose autoimmune thyroid disease, in particular Hashimoto’s Disease.
  • Reverse T3: This is created by the body from T4. Your body can either turn T4 into T3 or into reverse T3 based on what it needs. Factors that convert too much reverse T3 include high cortisol (stress), and poor liver function (fatty liver or methylation factors). 

Below is an example of a functional thyroid test showing these markers.

Why We Need Further Functional Testing

Once the thyroid hormone is happily swimming around your body via the bloodstream, it is not a sure thing that it will enter the cell and exert it’s action on the mitochondria. It needs to get past the cell wall. It has been thought that thyroid hormone enters the cell through passive diffusion, but researchers are now thinking it is more complicated than that.

Some researchers propose a membrane-mediated process of entry. The involvement of saturability, high specificity, sensitivity to temperature, sulfhydryl and cell-surface-perturbing reagents and hydrolytic enzymes.

This research highlights something we have known for years at The Lucy Rose Clinic. Just because there is ample thyroid hormone in the blood, does NOT mean you are getting all the metabolic advantages of it.

Down the rabbit hole

Conversion of thyroid hormones is controlled by enzymes, and these enzymes need specific nutrients to do their job.

Deiodinase type 1, type 2, and type 3 are the set of three enzymes that convert thyroid hormones in the human body. They are abbreviated D1, D2, and D3.

  • D1 focuses on converting RT3 and T3-Sulfate, and we still know little about T3S.
  • “D2 and D3 are usually not expressed together in the same cell” (Groeneweg, 2017)
  • D2 focuses on converting T4 into T3. It does not convert it into rT3.
  • A high rT3 issue is mediated by cells expressing too much D3.

In a person with a healthy thyroid, D2 and D3 are balanced throughout the body, and are ready to respond and adjust to changes in thyroidal secretion rate, thyroid secretion ratio, and health and environmental conditions.

When the body or a local tissue is attempting to compensate for illness, damage, and/or excess or low thyroid hormone, the deiodinases will become imbalanced by D3 dominance. It is essentially a self protective mechanism – but under certain circumstances can go awry.

This is one reason people can have so much trouble balancing thyroid medication.

Can we treat this?

The field of study that focuses on improving the health and status of your enzyme production is called Epigenetics.

“Epigenetics is the study of heritable changes in gene expression (active versus inactive genes) that do not involve changes to the underlying DNA sequence — a change in phenotype without a change in genotype — which in turn affects how cells read the genes.”

Scientists have discovered genetic polymorphisms in the genes DIO1 and DIO2 that make T4-T3 conversion less efficient.

However, having a genetic polymorphism is only a small fraction of the problem. My favourite quote that explains this is;

“Genes load the gun. Environment pulls the trigger”.

A large part of the function of these enzymes is regulated epigenetically, by environmental stimuli such as age, lifestyle choices, diet, toxin load, and disease status. And that is something we do have a lot of control over.

This is where we SHIINE!

Now it’s your turn! Book a free 15-minute consult to start your Ultimate Thyroid Health Journey today!

The Lucy Rose Clinic prides itself on being at the forefront of thyroid treatment using functional pathology and scientifically validated natural medicine solutions, coupled with correct diet, exercise, detox strategies, and lifestyle guidance to address all factors required to get you feeling well again.

BOOK NOW!

1What Is Nutritional Medicine?Impressive Withania Somnefera Study Demonstrates the POWER of Botanicals

Share this post?

Facebook Twitter Pinterest

About author

Lucy Rose Clinic

Naturopath and writer for The Lucy Rose Clinic.

More posts

  • Related
  • Popular
  • Latest
Treating Osteoarthritis Naturally
Treating Osteoarthritis Naturally
Irritable Bowel Syndrome and Thyroid
Irritable Bowel Syndrome and Thyroid
Graves Disease in Men
Graves Disease in Men
EBV and Thyroid Education Video
EBV and Thyroid Education Video
Is Iodine the Key to Weight Loss? Pt1 - Iodine & Weight Loss
Is Iodine the Key to Weight Loss? Pt1 - Iodine & Weight Loss
The Root Cause to Autoimmune Thyroiditis
The Root Cause to Autoimmune Thyroiditis
Let’s talk about Hydration and Salt! Why you can’t live without it!
Let’s talk about Hydration and Salt! Why you can’t live without it!
Garlic Bacon Wrapped Chicken Bites
Garlic Bacon Wrapped Chicken Bites
Warrigal Greens and Macadamia Pesto
Warrigal Greens and Macadamia Pesto
How Stress Affects Your Libido
How Stress Affects Your Libido
Treating Plantar Fasciitis Naturally
Treating Plantar Fasciitis Naturally
Treating Osteoarthritis Naturally
Treating Osteoarthritis Naturally

Search

Recent Podcast

  • The Thyroid and Menopause Complication
    April 4, 2022 by The Lucy Rose Clinic
  • Belly Fat - The Why and How Behind It
    March 14, 2022 by The Lucy Rose Clinic
  • #5 The Role Of The Liver In Optimal Wellness
    March 7, 2022 by The Lucy Rose Clinic
  • #3 Iodine Dosing misconceptions and safe use for thyroid health
    February 28, 2022 by The Lucy Rose Clinic
  • The REAL Reason You Have Brain Fog
    February 23, 2022 by The Lucy Rose Clinic

Categories

  • Autoimmune
  • Beauty
  • Complementary Practices
  • Conditions
  • Detoxification
  • Diagnosis & Testing
  • Endometriosis
  • Fatigue
  • Gut Health
  • Healing Diet
  • Hormones
  • Irritable Bowel Syndrome
  • Libido
  • Lifestyle
  • Liver health
  • Medication
  • Mens Health
  • Mental Health
  • Mood
  • Nodules & Growths
  • Nutrition
  • Osteoarthritis
  • Patient Stories
  • Plantar Fasciitis
  • Podcast
  • Quizzes & Questionnaires
  • Recipes
  • Sleep
  • Stress
  • Supplements
  • Thyroid
  • Thyroid Conditions
  • Uncategorized
  • Vitality Boosting Programs
  • Vlog
  • Weight

Follow Us

Recent Posts

  • Warrigal Greens and Macadamia Pesto
  • How Stress Affects Your Libido
  • Treating Plantar Fasciitis Naturally
  • Treating Osteoarthritis Naturally
  • Treating Endometriosis Naturally
Contact Info
Sydney CBD (Head Office), Suite 13, level 3, 247 Coward St. Mascot NSW 2020
1300 THYROID (1300 849 764)
info@thelucyroseclinic.com.auEmail Us
Contact Us
Open Hours
  • Monday 9am-5pm
  • Tuesday 9am-5pm
  • Wednesday 9am-5pm
  • Thrusday 9am-5pm
  • Friday 9am-5pm
Contact Us
Latest Articles
  • Warrigal Greens and Macadamia Pesto
  • How Stress Affects Your Libido
  • Treating Plantar Fasciitis Naturally
  • Treating Osteoarthritis Naturally
  • Treating Endometriosis Naturally
  • Prostate Health – Keeping a Healthy Prostate
  • What Causes Beer Belly?
  • Healing Sweet Potato Soup
  • Irritable Bowel Syndrome and Thyroid
  • The Effect of Iodine on Testosterone in Men
View More
Quick Links
  • Our Approach
  • FAQ
  • About Thyroid
  • Testing
  • Reviews
  • Articles
  • Contact Us
© 2020 The Lucy Rose Clinic. All Rights Reserved - Terms & Conditions - Privacy Policy
The Lucy rose clicnic

Privacy Policy. Visit Our Website.

Talk To Us Today - Click Here To Book An Appointment To Talk To An Experienced Practitioner

The Lucy Rose Clinic - Sydney CBD (Head Office), Suite 13, Level 1, 110 Sussex St, Sydney, NSW, 2000 - 1300 849 764

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Cookie settingsACCEPT
Privacy & Cookies Policy

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience.
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Non-necessary
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.
SAVE & ACCEPT